Synthesis Of Antimicrobial Powders For Tissue Engineering

This work focuses on the synthesis and physicochemical characterization of materials based on calcium phosphates for use as biomaterials, either for bone filling or recovery of bone prostheses. The synthesis of the powder materials was performed by precipitation in aqueous solution (Synthesis wet) at ambient temperature. Bioactive molecules were incorporated into apatite crystal structure, such as fluoride ions and antibacterial agents (Cu2+, Zn2+ ions) that accelerate the bone healing and preventing local infection around material. Many technical methods for physicochemical analysis such as X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Thermal Gravimetric Analysis/Differential Thermal Analysis (TGA/DTA) are used for the characterization of materials. The results show that the final product may consist of a pure phase (Apatite of formula (Ca, M)10(PO4)6(OH,F)2, with M=Cu2+, Zn2+)) or a mixture of various components in controlled proportions. The evaluation of antimicrobial effects conducted on powders is performed against pathogenic bacterial strains of Escherichia coli and Staphylococcus aureus. The results are very promising and demonstrate the improvement of antimicrobial properties of prepared material.