Synergistic Effect Of Epicatechin Coated Silver Nanoparticles On Antimicrobial Activity Of Gentamicin Against Aspergillus Niger

In present work, synergistic effect of epicatechin capped silver nanoparticles (ECAgNPs) with gentamicin was investigated in vitro and effect of ECAgNPs as a novel type of potential antimicrobial agent with gentamicin was observed. ECAgNPs with gentamicin showed remarkable antifungal activity when compared to the antifungal activities of epicatechin, gentamicin and silver nitrate. Gentamicin when combined with ECAgNPs revealed synergistic effect and this combination of ECAgNPs with gentamicin enhanced its minimum inhibitory concentration (MIC) value that is, 78.3. When antifungal activity of gentamicin, epicatechin and silver nitrate was observed then it was noticed that epicatechin didn’t possess antifungal effectiveness, whereas gentamicin and silver nitrate exhibited moderate antifungal effectiveness (MIC = 37.9) and (MIC = 35.4). Therefore, ECAgNPs induced antifungal effectiveness when combined with gentamicin.