The aim of the present study was to determine the chemical composition and to evaluate the acute
toxicity, antimicrobial and anti-inflammatory activities of Thymus fontanesii essential oils (TFEO). The oils
were obtained by hydrodistillation from the aerial parts of T. fontanesii at yield of 2.4±0.2%. Using GC and
GC/MS techniques, 24 compounds were identified representing more than 98% of the oil composition. The main
constituents were carvacrol (54.7±1.2%), p-cymene (17.5±0.3%) and ɣ-terpinene (8.8±0.6%). Using the disc
diffusion and broth microdilution methods against six microbial strains, the antimicrobial evaluation showed
that TFEO exhibited good antibacterial activity against all the strains tested except Pseudomonas aeruginosa.
The acute toxicity test of TFEO was conducted in mice by gavage in single doses of 100-3000 mg/kg. However,
the mortality rate as well as the acute toxicity of the oral administered oil increased progressively with
increasing dose (LD50=875mg/kg). Anti-inflammatory activity of TFEO was evaluated using carrageenaninduced
paw edema in mice. The paw edema was reduced by the TFEO at doses of 50 mg/kg (22.8%) and 100
mg/kg (62.2%). The TFEO was found to possess potent anti-inflammatory activity.Results of the present study
indicate that TFEO has a noteworthy potential for the use in pharmaceutical formulations.
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Posté Le : 18/02/2024
Posté par : einstein
Ecrit par : - Lamia Sidali Lamia - Moussa Brada Moussa - Fauconnier Marie-laure - Lognay Georges - Heuskin Stéphanie
Source : PhytoChem & BioSub Journal Volume 11, Numéro 1, Pages 30-40 2017-04-16