1,2,3-triazoles : Between Click Chemistry And Organoclick

The renewal of Huisgen 1,3-dipolar cycloaddition of alkyne and organic azide by Sharpless’s and Meldal’s groups has had enormously success with the use of copper as catalyst. This type of reaction qualified Click generates the 1,2,3-triazoles under mild conditions in a selective and rapid manner. Also, several organocatalysis synthesis reactions of 1,2,3-triazoles named Organoclick have been developed, by the use of carbonyl compounds, azides and secondary amine as catalyst. In this case, the 1,2,3-triazoles are obtained in the absence of metal, in ecological conditions, generally with very good yields and high selectivity